Ganta Srinivas, Deshpande Dipti, Korde Anisha, Amiji Mansoor
Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 110 Mugar Life Sciences Building, Boston, Massachusetts 02115, USA.
Mol Membr Biol. 2010 Oct;27(7):260-73. doi: 10.3109/09687688.2010.497971. Epub 2010 Oct 7.
The oral and central nervous systems (CNS) present a unique set of barriers to the delivery of important diagnostic and therapeutic agents. Extensive research over the past few years has enabled a better understanding of these physical and biological barriers based on tight cellular junctions and expression of active transporters and metabolizing enzymes at the luminal surfaces of the gastrointestinal (GI) tract and the blood-brain barrier (BBB). This review focuses on the recent understanding of transport across the GI tract and BBB and the development of nanotechnology-based delivery strategies that can enhance bioavailability of drugs. Multifunctional lipid nanosystems, such as oil-in-water nanoemulsions, that integrate enhancement in permeability, tissue and cell targeting, imaging, and therapeutic functions are especially promising. Based on strategic choice of edible oils, surfactants and additional surface modifiers, and different types of payloads, rationale design of multifunctional nanoemulsions can serve as a safe and effective delivery vehicle across oral and CNS barriers.
口腔和中枢神经系统（CNS）对重要诊断和治疗药物的递送构成了一系列独特的屏障。过去几年的广泛研究使人们能够基于紧密的细胞连接以及胃肠道（GI）和血脑屏障（BBB）腔表面上活性转运蛋白和代谢酶的表达，更好地理解这些物理和生物屏障。本综述重点关注对跨胃肠道和血脑屏障转运的最新认识以及基于纳米技术的递送策略的发展，这些策略可提高药物的生物利用度。多功能脂质纳米系统，如水包油纳米乳液，整合了通透性增强、组织和细胞靶向、成像及治疗功能，尤其具有前景。基于对食用油、表面活性剂和其他表面改性剂的策略性选择以及不同类型的载药，多功能纳米乳液的合理设计可作为一种安全有效的递送载体跨越口腔和中枢神经系统屏障。
