Souto E B, Nayak A P, Murthy R S R
Institute of Biotechnology and Bioengineering, Centre of Genomics and Biotechnology University of Trás-os-Montes and Alto Douro (IBB/CGB-UTAD), Vila-Real, Portugal.
Pharmazie. 2011 Jul;66(7):473-8.
Multifunctional lipid nanoemulsions have shown to combine several advantages e.g. tissue targeting, cell targeting, imaging analysis, barrier permeability enhancement, and therapeutic purposes. Depending on the choice of lipid composition, surfactants and additional surface modifiers ratio, different drug loadings may be achieved and exploited for drug delivery in cancer chemotherapy. However, a safe and effective delivery system for cancer therapy should also be able to overcome the major impediment of multidrug resistance. Several strategies have been tested in nanoemulsions including P-glycoprotein-mediated drug resistance. The present review focuses on a comprehensive discussion of the use of nanoemulsions in anti-cancer therapy, reporting the technological aspects of pharmaceutical formulation of these carriers, and exploiting their advantages in siRNA therapy.
多功能脂质纳米乳剂已显示出具有多种优势，例如组织靶向、细胞靶向、成像分析、增强屏障通透性以及用于治疗目的。根据脂质组成、表面活性剂和其他表面改性剂比例的选择，可以实现不同的载药量，并将其用于癌症化疗中的药物递送。然而，一种安全有效的癌症治疗递送系统还应能够克服多药耐药这一主要障碍。已经在纳米乳剂中测试了多种策略，包括P-糖蛋白介导的耐药性。本综述着重全面讨论纳米乳剂在抗癌治疗中的应用，报告这些载体药物制剂的技术方面，并探讨它们在siRNA治疗中的优势。
