Alfei Silvana, Zuccari Guendalina
Department of Pharmacy (DIFAR), University of Genoa, Via Cembrano 4, 16148 Genoa, Italy.
Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147 Genoa, Italy.
Nanomaterials (Basel). 2025 Feb 10;15(4):265. doi: 10.3390/nano15040265.
Currently, nanotechnology is the most promising science, engineering, and technology conducted at the nanoscale (nm), which is used in several sectors. Collectively, nanotechnology is causing a new industrial revolution, and nano-based products are becoming increasingly important for the global market and economy. The interest in nanomaterials has been strongly augmented during the last two decades, and this fact can be easily evaluated by considering the number of studies present in the literature. In November 2024, they accounted for 764,279 experimental studies developed in the years 2009-2024. During such a period, our group contributed to the field of applicative nanotechnology with several experimental and review articles, which we hope could have relevantly enhanced the knowledge of the scientific community. In this new publication, an exhaustive overview regarding the main types of developed nanomaterials, the characterization techniques, and their applications has been discussed. Particular attention has been paid to nanomaterials employed for the enhancement of bioavailability and delivery of bioactive molecules and to those used for ameliorating traditional food packaging. Then, we briefly reviewed our experimental studies on the development of nanoparticles (NPs), dendrimers, micelles, and liposomes for biomedical applications by collecting inherent details in a reader-friendly table. A brief excursus about our reviews on the topic has also been provided, followed by the stinging question of nanotoxicology. Indeed, although the application of nanotechnology translates into a great improvement in the properties of non-nanosized pristine materials, there may still be a not totally predictable risk for humans, animals, and the environment associated with an extensive application of NPs. Nanotoxicology is a science in rapid expansion, but several sneaky risks are not yet fully disclosed. So, the final part of this study discusses the pending issue related to the possible toxic effects of NPs and their impact on customers' acceptance in a scenario of limited knowledge.
目前,纳米技术是在纳米尺度(nm)上进行的最具前景的科学、工程和技术,它被应用于多个领域。总体而言,纳米技术正在引发一场新的工业革命,基于纳米的产品对全球市场和经济变得越来越重要。在过去二十年中,对纳米材料的兴趣急剧增加,这一事实通过考虑文献中现有研究的数量就可以很容易地评估出来。在2024年11月,它们占2009 - 2024年开展的764,279项实验研究。在这一时期,我们团队通过多篇实验和综述文章为应用纳米技术领域做出了贡献,我们希望这些文章能显著增进科学界的知识。在这篇新发表的文章中,已经讨论了关于已开发的主要纳米材料类型、表征技术及其应用的详尽概述。特别关注了用于提高生物活性分子的生物利用度和递送的纳米材料,以及用于改善传统食品包装的纳米材料。然后,我们通过以读者友好的表格形式收集内在细节,简要回顾了我们关于用于生物医学应用的纳米颗粒(NPs)、树枝状大分子、胶束和脂质体开发的实验研究。还提供了关于我们对该主题综述的简要介绍,随后是纳米毒理学这一尖锐问题。的确,尽管纳米技术的应用转化为非纳米级原始材料性能的巨大提升,但与纳米颗粒的广泛应用相关的对人类、动物和环境的风险可能仍然不完全可预测。纳米毒理学是一门迅速发展的科学,但一些潜在风险尚未完全揭示。因此,本研究的最后一部分讨论了与纳米颗粒可能的毒性作用相关的悬而未决的问题,以及在知识有限的情况下它们对客户接受度的影响。