简短通讯：定量蛋白质组血浆分析揭示慢性猴免疫缺陷病毒（SIV）与甲基苯丙胺共病时宿主对氧化应激的防御激活。
Short communication: quantitative proteomic plasma profiling reveals activation of host defense to oxidative stress in chronic SIV and methamphetamine comorbidity.
作者信息
Pendyala Gurudutt, Trauger Sunia A, Siuzdak Gary, Fox Howard S
机构信息
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, 68198-5800, USA.
出版信息
AIDS Res Hum Retroviruses. 2011 Feb;27(2):179-82. doi: 10.1089/aid.2010.0090. Epub 2010 Oct 7.
Abstract
The double epidemic of substance abuse and HIV infection is a multifaceted problem To investigate mechanistic clues to the effects of substance abuse on infected individuals we preformed quantitative proteomic profiling of plasma in a methamphetamine treated nonhuman primate model for AIDS. A nontargeted quantitative approach identified extracellular superoxide dismutase to be significantly upregulated by SIV and methamphetamine treatment, and targeted studies revealed an increase in expression in the antioxidant glutathione S-transferase, thus pointing to a compensatory response to increased oxidative stress in methamphetamine-treated animals.
摘要
药物滥用和艾滋病毒感染的双重流行是一个多方面的问题。为了研究药物滥用对受感染个体影响的机制线索，我们在一个用于艾滋病研究的经甲基苯丙胺处理的非人类灵长类动物模型中，对血浆进行了定量蛋白质组分析。一种非靶向定量方法确定，细胞外超氧化物歧化酶在感染猴免疫缺陷病毒（SIV）和经甲基苯丙胺处理后显著上调，靶向研究显示抗氧化剂谷胱甘肽S-转移酶的表达增加，从而表明在经甲基苯丙胺处理的动物中对氧化应激增加存在代偿反应。
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