中国恒河猴对猴免疫缺陷病毒感染的易感性。

Susceptibility of Chinese rhesus monkeys to SIV infection.

作者信息

Burdo Tricia H, Marcondes Maria Cecilia G, Lanigan Caroline M S, Penedo Maria Cecilia T, Fox Howard S

机构信息

Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA.

出版信息

AIDS. 2005 Oct 14;19(15):1704-6. doi: 10.1097/01.aids.0000186823.76230.33.

DOI:10.1097/01.aids.0000186823.76230.33

PMID:16184046

Abstract

The use of China-derived monkeys in AIDS research has been limited by reports of reduced susceptibility to SIV. We performed a serial passage of SIV in Chinese macaques, which resulted in a viral stock capable of inducing simian AIDS and high levels of replication in these animals. Similar to HIV in humans, SIV pathogenesis in non-human primates is not limited by geographical origin. Chinese macaques are useful in pathogenesis, vaccine, and therapeutic studies in AIDS.

摘要

源自中国的猴子在艾滋病研究中的应用受到了对猴免疫缺陷病毒（SIV）易感性降低报道的限制。我们在中国猕猴中对SIV进行了连续传代，从而获得了一种病毒株，该病毒株能够在这些动物中诱发猴艾滋病并实现高水平复制。与人类中的人类免疫缺陷病毒（HIV）类似，非人灵长类动物中SIV的发病机制不受地理来源的限制。中国猕猴在艾滋病的发病机制、疫苗及治疗研究中具有重要作用。