Madak Nihat, Nazlı Yunus, Mergen Haluk, Aysel Süleyman, Kandaz Muhammet, Yanık Ekrem, Cekdemir Demet, Tavlı Talat
Department of Cardiology, Faculty of Medicine, University of Celal Bayar, Manisa, Turkey.
Anadolu Kardiyol Derg. 2010 Oct;10(5):416-20. doi: 10.5152/akd.2010.139.
In this study, we sought to investigate the serum levels of high sensitivity C-reactive protein (Hs-CRP), N-terminal pro-brain natriuretic peptide (NT proBNP), erythrocyte sedimentation rate, leukocyte, thyroid hormone and fibrinogen levels in patients with coronary slow flow phenomenon (CSFP).
A total of 82 patients with angiographically proven normal coronary arteries and slow coronary flow in all three coronary vessels (45 males and 37 females, mean age 59±11 years) and 34 patients with normal coronary arteries and normal coronary flow (19 males and 15 females, mean age 56±10 years) with similar risk profiles were included in this cross-sectional observational study. Coronary flow rates of all patients and control subjects were documented by Thrombolysis In Myocardial Infarction (TIMI) frame count, serum level of Hs-CRP, NT proBNP, sedimentation, leukocyte, free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH) and fibrinogen levels were measured. Statistical analysis was performed using t test for independent samples, Chi-square test and Pearson correlation analysis.
Hs-CRP (0.88±0.86 vs 0.36±0.35 mg/L, p=0.001) and NT proBNP (117.83±163.2 vs 47.33±30.6 ng/ml, p=0.01) were found to be significantly higher in patients with coronary slow flow compared with normal control group. There were no significant differences regarding thyroid hormones, fibrinogen, sedimentation rate and leukocyte count between two groups. The mean TIMI frame counts were positively correlated (r=0.454, p=0.001 and r=0.554, p=0.001, respectively) with plasma Hs-CRP levels and NT-proBNP levels.
Hs-CRP and NT proBNP are significantly higher in patients with coronary slow flow compared with normal control group. Their increased levels are positively correlated with TIMI frame count.
在本研究中，我们试图调查冠状动脉慢血流现象（CSFP）患者的血清高敏C反应蛋白（Hs-CRP）、N末端脑钠肽前体（NT proBNP）、红细胞沉降率、白细胞、甲状腺激素和纤维蛋白原水平。
本横断面观察性研究纳入了82例经血管造影证实冠状动脉正常但三支冠状动脉血流缓慢的患者（45例男性和37例女性，平均年龄59±11岁）以及34例冠状动脉正常且血流正常的患者（19例男性和15例女性，平均年龄56±10岁），两组患者的风险特征相似。通过心肌梗死溶栓（TIMI）帧数记录所有患者和对照者的冠状动脉血流速度，测量血清Hs-CRP、NT proBNP、血沉、白细胞、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、促甲状腺激素（TSH）和纤维蛋白原水平。采用独立样本t检验、卡方检验和Pearson相关分析进行统计学分析。
发现冠状动脉慢血流患者的Hs-CRP（0.88±0.86 vs 0.36±0.35 mg/L，p=0.001）和NT proBNP（117.83±163.2 vs 47.33±30.6 ng/ml，p=0.01）显著高于正常对照组。两组之间甲状腺激素、纤维蛋白原、血沉率和白细胞计数无显著差异。平均TIMI帧数与血浆Hs-CRP水平和NT-proBNP水平呈正相关（分别为r=0.454，p=0.001和r=0.554，p=0.001）。
冠状动脉慢血流患者的Hs-CRP和NT proBNP显著高于正常对照组。它们水平的升高与TIMI帧数呈正相关。
