Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Mol Cell. 2010 Oct 8;40(1):5-7. doi: 10.1016/j.molcel.2010.09.016.
The membrane-spanning C-terminal regions in tail-anchored proteins must be recognized and delivered posttranslationally to the endoplasmic reticulum or mitochondrial membrane. A paper in this issue of Molecular Cell (Wang et al., 2010) and another recent report (Mariappan et al., 2010) delineate early steps in this pathway.
尾部锚定蛋白的跨膜 C 端区域必须被识别,并在翻译后递送至内质网或线粒体膜。本期《分子细胞》杂志的一篇论文(Wang 等人,2010)和另一篇近期报告(Mariappan 等人,2010)阐述了该途径的早期步骤。