Heidelberg University Biochemistry Center, INF 328, 69120 Heidelberg, Germany.
Structure. 2011 Oct 12;19(10):1353-5. doi: 10.1016/j.str.2011.10.001.
Tail-anchored (TA) membrane proteins perform essential cellular functions. They are posttranslationally inserted into the endoplasmic reticulum (ER) membrane by interaction of the Get3 chaperone with the Get1/2 receptor. Two independent structural and functional analyses of the Get3/receptor complex by Stefer et al. and Mariappan et al. now provide insights into TA protein insertion.
尾部锚定（TA）膜蛋白执行重要的细胞功能。它们通过 Get3 伴侣与 Get1/2 受体的相互作用，在翻译后被插入内质网（ER）膜中。Stefer 等人和 Mariappan 等人对 Get3/受体复合物进行了两项独立的结构和功能分析，现在为 TA 蛋白插入提供了深入了解。
