内质网中的蛋白质折叠和质量控制。
Protein folding and quality control in the ER.
机构信息
Laboratory of Molecular and Cellular Biology, Faculty of Life Sciences, Kyoto Sangyo University, Kamigamo, Kita-ku, Kyoto 803-8555, Japan.
出版信息
Cold Spring Harb Perspect Biol. 2011 Nov 1;3(11):a007526. doi: 10.1101/cshperspect.a007526.
Abstract
The endoplasmic reticulum (ER) uses an elaborate surveillance system called the ER quality control (ERQC) system. The ERQC facilitates folding and modification of secretory and membrane proteins and eliminates terminally misfolded polypeptides through ER-associated degradation (ERAD) or autophagic degradation. This mechanism of ER protein surveillance is closely linked to redox and calcium homeostasis in the ER, whose balance is presumed to be regulated by a specific cellular compartment. The potential to modulate proteostasis and metabolism with chemical compounds or targeted siRNAs may offer an ideal option for the treatment of disease.
摘要
内质网 (ER) 使用一种称为内质网质量控制 (ERQC) 系统的精细监控系统。ERQC 促进分泌蛋白和膜蛋白的折叠和修饰，并通过内质网相关降解 (ERAD) 或自噬降解消除末端错误折叠的多肽。这种内质网蛋白监控机制与内质网中的氧化还原和钙稳态密切相关，其平衡被认为受特定细胞区室调节。用化学化合物或靶向 siRNA 调节蛋白质平衡和代谢的潜力可能为疾病治疗提供理想的选择。
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