Department of Toxicology, Medical University of Silesia, 4 Jagiellonska Street, 41-200 Sosnowiec, Poland.
Ecotoxicol Environ Saf. 2011 May;74(4):630-5. doi: 10.1016/j.ecoenv.2010.09.012. Epub 2010 Oct 6.
Nickel is applied in the production of surgical instruments and compounds of nickel affect the osseous tissue. The objective of this study was to determine the contents of nickel and 11 elements in tissues of a hip joint obtained from inhabitants of the Upper-Silesian Industrial Area. The samples were collected intra-operatively during Total Hip Replacement procedures, in most cases the indication for the surgery was hip osteoarthritis. Concentrations of nickel and 11 trace elements were measured with a Pye Unicam SP-9 acetylene-oxygen flame atomic absorption spectrometer (AAS). Additional analyses were conducted to identify the correlations occurring between these elements. The average content of trace elements in the hip joint was as follows (mg kg(-1)): Cd 0.66, Cr 7.58, Cu 8.43, Mn 0.79, Pb 3.75, Ni 4.82, Fe 252.13, Zn 75.65, Mg 1306.19, K 3938.67, Na 7484.52, Ca 49485.44. The study demonstrated that the content of nickel and the other elements was diversified, depending on the element of the hip joint, gender and the type of affection the endoprosthesis-plasty was performed for.
镍被应用于外科器械的生产,镍的化合物会影响骨骼组织。本研究的目的是测定上西里西亚工业区居民髋关节组织中镍和 11 种元素的含量。这些样本是在全髋关节置换手术过程中采集的,手术的主要指征是髋关节骨关节炎。镍和 11 种微量元素的浓度是用 Pye Unicam SP-9 乙炔-氧火焰原子吸收光谱仪(AAS)测量的。此外还进行了其他分析以确定这些元素之间的相关性。髋关节中微量元素的平均含量(mg/kg)如下:Cd 0.66、Cr 7.58、Cu 8.43、Mn 0.79、Pb 3.75、Ni 4.82、Fe 252.13、Zn 75.65、Mg 1306.19、K 3938.67、Na 7484.52、Ca 49485.44。研究表明,镍和其他元素的含量因髋关节的部位、性别以及进行假体成形术的疾病类型而有所不同。