Kunz J, Haberland H, Schmidt A, Amendt P
Institut für Pathologie des Bezirkskrankenhauses Potsdam, Deutschland.
Acta Histochem. 1990;89(2):131-40.
The histologic features and morphometric data of the endocrine pancreas (surgical specimens) of 12 infants suffering from persistent hyperinsulinemic hypoglycemia are reported. In 3 cases, a focal nesidioblastosis, in another 3 cases, a diffuse nesidioblastosis were observed. 2 infants demonstrate B-cell adenomata and 4 adenomata combined with a diffuse nesidioblastosis. In respect to volume density of the endocrine pancreas and diameter of the islets, there are no differences between cases with diffuse nesidioblastosis and age-matched controls. Structural changes of the endocrine pancreas in cases with nesidioblastosis are detectable by their chromogranin-A-immunoreactivity. Further investigations are necessary to clarify if there are disturbances in the relationships between chromogranin A and peptide hormones additionally to structural changes in the pancreas.
报告了12例持续性高胰岛素血症低血糖症婴儿内分泌胰腺（手术标本）的组织学特征和形态计量学数据。3例观察到局灶性胰岛细胞增殖症，另外3例观察到弥漫性胰岛细胞增殖症。2例婴儿表现为B细胞腺瘤，4例为腺瘤合并弥漫性胰岛细胞增殖症。就内分泌胰腺的体积密度和胰岛直径而言，弥漫性胰岛细胞增殖症病例与年龄匹配的对照组之间没有差异。胰岛细胞增殖症病例中内分泌胰腺的结构变化可通过嗜铬粒蛋白A免疫反应性检测到。需要进一步研究以阐明除胰腺结构变化外，嗜铬粒蛋白A与肽类激素之间的关系是否存在紊乱。
