Synthesis and absolute configurations of the cytotoxic polyacetylenes isolated from the callus of Panax ginseng.
作者信息
Fujimoto Y, Satoh M, Takeuchi N, Kirisawa M
机构信息
Nihon University, College of Pharmacy, Chiba, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1990 Jun;38(6):1447-50. doi: 10.1248/cpb.38.1447.
PMID:2093310
Abstract
Panaxacol (1) and dihydropanaxacol (2), cytotoxic polyacetylenes isolated from the callus of Panax ginseng, were synthesized starting from D-(-)-diethyl tartrate. The absolute configuration of 1 was determined to be 9R, 10R and the absolute configuration at C-3 of 2 was tentatively assigned as 3S by the application of the R(+)-alpha-methoxy-alpha-(trifluoro methyl)phenylacetyl (MTPA) method.
摘要
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