Division of Dermatology, University of Louisville, 310 East Broadway, Louisville, KY 40202, USA.
Dermatol Ther. 2012 Mar-Apr;25(2):158-72. doi: 10.1111/j.1529-8019.2012.01488.x.
Neutrophilic dermatoses, including Sweet's syndrome, pyoderma gangrenosum, and rheumatoid neutrophilic dermatitis, are inflammatory conditions of the skin often associated with underlying systemic disease. These are characterized by the accumulation of neutrophils in the skin. The associated conditions, potential for systemic neutrophilic infiltration, and therapeutic management of these disorders can be similar. Sweet's syndrome can often be effectively treated with a brief course of systemic corticosteroids. Pyoderma gangrenosum, however, can be recurrent, and early initiation of a steroid-sparing agent is prudent. Second-line treatment for both of these conditions includes medications affecting neutrophil function, in addition to immunosuppressant medications.
中性粒细胞皮肤病，包括Sweet 综合征、坏疽性脓皮病和类风湿性中性粒细胞皮肤病，是皮肤的炎症性疾病，常与潜在的系统性疾病有关。这些疾病的特征是中性粒细胞在皮肤中积聚。相关疾病、潜在的全身中性粒细胞浸润以及这些疾病的治疗管理可能相似。Sweet 综合征通常可以通过短期全身皮质类固醇治疗有效地治疗。然而，坏疽性脓皮病可能会反复发作，早期开始使用类固醇保留剂是明智的。这两种疾病的二线治疗包括影响中性粒细胞功能的药物，以及免疫抑制剂药物。
