Discipline of Clinical and Experimental Pathophysiology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Nutrition. 2011 Jun;27(6):666-71. doi: 10.1016/j.nut.2010.07.012. Epub 2010 Oct 8.
An inverse relation between dietary calcium and adiposity has been found in several epidemiologic studies. Recent evidence has also suggested that a calcium-rich diet may have beneficial effects on insulin resistance and dyslipidemia. This study aimed to evaluate the association of dietary calcium intake with global adiposity, abdominal obesity, and metabolic profile in hypertensive patients.
In this cross-sectional study, 85 hypertensive patients 25 to 70 y old underwent clinical, dietary, anthropometric, and biochemical evaluations. Participants were stratified into the following two groups according to their usual dietary calcium intake: low calcium group (<800 mg/d) and high calcium group (≥800 mg/d).
Fifty-seven participants (11 men and 46 women) were included in the final analyses. Subjects in the low calcium group compared with those in the high calcium group exhibited significantly higher levels of body mass index and percentage of body fat after adjustments for variables that could interfere with those adiposity parameters (P = 0.03 and 0.01, respectively). Patients in the high calcium group had a lower odds ratio for prevalent obesity than those in the low calcium group, even after controlling for potential confounders (P = 0.01). No significant differences were found in abdominal adiposity and metabolic profile between the two groups. Using data from all patients, an inverse and significant association was observed between dietary calcium intake and percentage of body fat, and it remained after controlling for confounders (P = 0.03).
The findings of the present study suggest that, in hypertensive patients, higher dietary calcium intake could be associated with lower global adiposity.
多项流行病学研究发现，膳食钙与肥胖呈负相关。最近的证据还表明，富含钙的饮食可能对胰岛素抵抗和血脂异常有有益影响。本研究旨在评估高血压患者膳食钙摄入量与全身肥胖、腹型肥胖和代谢特征的相关性。
在这项横断面研究中，85 名 25 至 70 岁的高血压患者接受了临床、饮食、人体测量和生化评估。根据他们的日常膳食钙摄入量，将参与者分为以下两组：低钙组（<800mg/d）和高钙组（≥800mg/d）。
最终有 57 名参与者（11 名男性和 46 名女性）纳入了最终分析。在校正可能干扰这些肥胖参数的变量后，低钙组的参与者与高钙组的参与者相比，体重指数和体脂百分比明显更高（分别为 P = 0.03 和 0.01）。即使在控制了潜在混杂因素后，高钙组患者发生肥胖的比值比仍低于低钙组（P = 0.01）。两组之间的腹部肥胖和代谢特征没有显著差异。对所有患者的数据进行分析，发现膳食钙摄入量与体脂百分比呈负相关，且在控制混杂因素后仍有统计学意义（P = 0.03）。
本研究的结果表明，在高血压患者中，较高的膳食钙摄入量可能与较低的全身肥胖有关。
