Center for Chronobiology, University of California - San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0116, United States.
Curr Opin Genet Dev. 2010 Dec;20(6):619-25. doi: 10.1016/j.gde.2010.09.002. Epub 2010 Oct 9.
The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 is built on a three-protein central oscillator that can be reconstituted in vitro, a redox-sensitive input for synchronization with the environment, and a bacterial two-component signal transduction pathway for global transcriptional regulation. This review covers the most recent progress in our understanding of the biological and biochemical mechanism of this bacterial clock, such as the discovery of a quinone-binding activity of the oscillator protein KaiA, the molecular mechanism of circadian control of cell division, and the global control of gene expression via modulation of DNA topology.
聚球藻 PCC 7942 的生物钟是建立在一个由三种蛋白质组成的中央振荡器上的，这个振荡器可以在体外重建，它有一个对环境同步的氧化还原敏感输入，还有一个细菌双组分信号转导途径用于全局转录调控。这篇综述涵盖了我们对这种细菌钟的生物学和生物化学机制的最新理解，例如振荡器蛋白 KaiA 的醌结合活性的发现、细胞分裂的生物钟控制的分子机制，以及通过调节 DNA 拓扑结构对基因表达的全局控制。
