Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, United States.
Curr Opin Microbiol. 2010 Dec;13(6):720-6. doi: 10.1016/j.mib.2010.09.012. Epub 2010 Oct 9.
Recent investigations have established core principles by which septins can form non-polar filaments in vitro. How cells then assemble, regulate and use septin polymers is still only beginning to be understood. It is clear that there is plasticity and variability in septin organization across diverse species and cell types. Work in the filamentous fungi has been invaluable in discovering this variation in form and function. In particular filamentous fungi display many forms of higher order septin structures and study of septins in these systems has led to insights into septin assembly, dynamics and regulation. Importantly in many cases work in these alternative systems reveal differences to how septins may be organized, functioning or regulated in Saccharomyces cerevisiae. Here I review the novel aspects of septin biology found in filamentous fungi and raise many open questions about these enigmatic polymers that should guide future study.
最近的研究已经确定了核心原则，即隔蛋白可以在体外形成非极性纤维。然而，细胞如何组装、调节和使用隔蛋白聚合物才刚刚开始被理解。很明显，在不同的物种和细胞类型中，隔蛋白的组织具有可塑性和可变性。丝状真菌的研究在发现这种形式和功能的变化方面非常有价值。特别是，丝状真菌表现出许多形式的高级隔蛋白结构，对这些系统中的隔蛋白的研究导致了对隔蛋白组装、动力学和调节的深入了解。重要的是，在许多情况下，这些替代系统中的工作揭示了隔蛋白在酿酒酵母中可能的组织、功能或调节方式的差异。在这里，我回顾了丝状真菌中发现的隔蛋白生物学的新方面，并提出了许多关于这些神秘聚合物的开放性问题，这些问题应该指导未来的研究。
