NFAT transcription factors, the potion mediating "Dr. Jekill-Mr. Hyde" transformation of the TGFβ pathway in cancer cells.
作者信息
Fernandez-Zapico Martin E, Ellenrieder Volker
出版信息
Cell Cycle. 2010 Oct 1;9(19):3838-9. doi: 10.4161/cc.9.19.13413. Epub 2010 Oct 23.
Abstract
摘要
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本文引用的文献
1
Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-beta switch from a suppressor to a promoter of cancer cell proliferation.NFAT 和 c-Myc 转录因子的级联激活介导了 TGF-β从肿瘤细胞增殖的抑制剂向促进剂的转换。
J Biol Chem. 2010 Aug 27;285(35):27241-27250. doi: 10.1074/jbc.M110.100438. Epub 2010 Jun 1.
2
TGFbeta signalling: a complex web in cancer progression.TGFbeta 信号通路：癌症进展中的复杂网络。
Nat Rev Cancer. 2010 Jun;10(6):415-24. doi: 10.1038/nrc2853.
3
NFAT-induced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells.NFAT 诱导的组蛋白乙酰化接力开关促进胰腺癌细胞中 c-Myc 依赖性生长。
Gastroenterology. 2010 Mar;138(3):1189-99.e1-2. doi: 10.1053/j.gastro.2009.10.045. Epub 2009 Nov 6.
4
NFAT proteins: emerging roles in cancer progression.NFAT蛋白：在癌症进展中的新作用。
Nat Rev Cancer. 2009 Nov;9(11):810-20. doi: 10.1038/nrc2735.
5
TGFbeta in Cancer.癌症中的转化生长因子β
Cell. 2008 Jul 25;134(2):215-30. doi: 10.1016/j.cell.2008.07.001.
6
TGFbeta regulated gene expression by Smads and Sp1/KLF-like transcription factors in cancer.转化生长因子β通过Smads和Sp1/KLF样转录因子调控癌症中的基因表达。
Anticancer Res. 2008 May-Jun;28(3A):1531-9.
7
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Cell. 2002 Jul 12;110(1):19-32. doi: 10.1016/s0092-8674(02)00801-2.
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