Institute of Diabetes Research, Helmholtz Zentrum Muenchen,German Research Center for Environmental Health (GmbH), Munich, Germany.
Int J Cancer. 2014 Apr 15;134(8):1767-75. doi: 10.1002/ijc.28329. Epub 2013 Jul 24.
Nuclear factor of activated T cells (NFAT) was first identified as a transcription factor which is activated upon T cell stimulation. Subsequent studies uncovered that a whole family of individual NFAT proteins exists with pleiotropic functions not only in immune but also in nonimmune cells. However, dysregulation of NFAT thereby favors malignant growth and cancer. Summarizing the recent advances in understanding how individual NFAT factors regulate the immune system, this review gives new insights into the critical role of NFAT in cancer development with special focus on inflammation-associated colorectal cancer.
核因子活化 T 细胞（NFAT）最初被鉴定为一种转录因子，在 T 细胞受到刺激时被激活。随后的研究揭示了存在一整套个体 NFAT 蛋白家族，它们具有多种功能，不仅在免疫细胞中，而且在非免疫细胞中也具有多种功能。然而，NFAT 的失调有利于恶性生长和癌症。本文总结了在理解单个 NFAT 因子如何调节免疫系统方面的最新进展，为 NFAT 在癌症发展中的关键作用提供了新的见解，特别关注了与炎症相关的结直肠癌。
