自噬在胰腺β细胞和糖尿病中的双刃剑效应。
The double-edged effect of autophagy in pancreatic beta cells and diabetes.
机构信息
Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
出版信息
Autophagy. 2011 Jan;7(1):12-6. doi: 10.4161/auto.7.1.13607. Epub 2011 Jan 1.
Abstract
Autophagy is an intracellular catabolic system, which enables cells to capture cytoplasmic components for degradation within lysosomes. Autophagy is involved in development, differentiation and tissue remodeling in various organisms, and is also implicated in certain diseases. Recent studies demonstrate that autophagy is necessary to maintain architecture and function of pancreatic beta cells. Altered autophagy is also involved in pancreatic beta cell death. Whether autophagy plays a protective or harmful role in diabetes is still not clear. In this review, we will summarize the current knowledge about the role of autophagy in pancreatic beta cell and diabetes.
摘要
自噬是一种细胞内的分解代谢系统，使细胞能够将细胞质成分捕获到溶酶体中进行降解。自噬参与各种生物体的发育、分化和组织重塑，也与某些疾病有关。最近的研究表明，自噬对于维持胰腺β细胞的结构和功能是必需的。自噬的改变也与胰腺β细胞的死亡有关。自噬在糖尿病中是发挥保护作用还是有害作用尚不清楚。在这篇综述中，我们将总结自噬在胰腺β细胞和糖尿病中的作用的现有知识。
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