Perzanowski Matthew S, Divjan Adnan, Mellins Robert B, Canfield Stephen M, Rosa Maria Jose, Chew Ginger L, Rundle Andrew, Goldstein Inge F, Jacobson Judith S
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
J Asthma. 2010 Nov;47(9):1015-21. doi: 10.3109/02770903.2010.513075.
Fractional exhaled nitric oxide (FeNO) has been proposed as a biomarker of airway inflammation for cohort studies of asthma.
To assess the association between FeNO and asthma symptoms among 7-year-old children living in an inner-city community. To test the association between environmental tobacco smoke (ETS) exposure (previous and current) and FeNO among these children.
As part of a longitudinal study of asthma, children recruited in Head Start centers at age 4 had offline FeNO and lung function testing at age 7. Children with allergen-specific immunoglobulin E (IgE) (≥0.35 IU/mL) at age 7 were considered seroatopic. ETS exposure at ages 4 and 7 was assessed by questionnaire.
Of 144 participating children, 89 had complete questionnaire data and achieved valid FeNO and lung function tests. Children with reported wheeze in the previous 12 months (n = 19) had higher FeNO than those without wheeze (n = 70) (geometric means 17.0 vs. 11.0 ppb, p = .005). FeNO remained significantly associated with wheeze (p = .031), after adjusting for seroatopy and forced expiratory volume in 1 second (FEV₁) in multivariable regression. FeNO at age 7 was positively associated with domestic ETS exposure at age 4 (29%) (β = 0.36, p = .015) but inversely associated with ETS exposure at age 7 (16%) (β = -0.74, p < .001).
Given its association with current wheeze, independent of seroatopy and lung function, FeNO provides a relevant outcome measure for studies in inner-city communities. While compelling, the positive association between ETS exposure at age 4 and a marker of airway inflammation at age 7 should be confirmed in a larger study.
呼出一氧化氮分数（FeNO）已被提议作为哮喘队列研究中气道炎症的生物标志物。
评估内城区社区7岁儿童中FeNO与哮喘症状之间的关联。测试这些儿童中环境烟草烟雾（ETS）暴露（既往和当前）与FeNO之间的关联。
作为哮喘纵向研究的一部分，4岁时在启蒙中心招募的儿童在7岁时进行离线FeNO和肺功能测试。7岁时患有过敏原特异性免疫球蛋白E（IgE）（≥0.35 IU/mL）的儿童被视为血清过敏。通过问卷评估4岁和7岁时的ETS暴露情况。
在144名参与研究的儿童中，89名有完整的问卷数据，并完成了有效的FeNO和肺功能测试。在过去12个月内有喘息报告的儿童（n = 19）的FeNO高于无喘息儿童（n = 70）（几何平均值分别为17.0 vs. 11.0 ppb，p = 0.005）。在多变量回归中，在调整血清过敏和1秒用力呼气量（FEV₁）后，FeNO与喘息仍显著相关（p = 0.031）。7岁时的FeNO与4岁时家庭ETS暴露（29%）呈正相关（β = 0.36，p = 0.015），但与7岁时的ETS暴露（16%）呈负相关（β = -0.74，p < 0.001）。
鉴于FeNO与当前喘息相关，且独立于血清过敏和肺功能，FeNO为内城区社区研究提供了一个相关的结局指标。虽然很有说服力，但4岁时ETS暴露与7岁时气道炎症标志物之间的正相关应在更大规模的研究中得到证实。
