Zhang Han, Shu Linhua, Cai Xuxu, Wang Zhijia, Jiao Xuyong, Liu Fen, Hou Ping, Wang Li, Shan Lishen, Chen Ning, Shang Yunxiao
Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.
Exp Ther Med. 2013 Apr;5(4):1174-1178. doi: 10.3892/etm.2013.922. Epub 2013 Jan 23.
Asthma is a chronic inflammatory disorder of the lung and diagnosis is difficult in children. The measurement of fractional exhaled nitric oxide (FeNO) may be useful in the diagnosis and monitoring of treatments. A number of factors affect FeNO levels and their influence varies across countries and regions. This study included 300 healthy students, aged from 6 to 14 years, who participated voluntarily. A comprehensive medical survey was used and measurements of FeNO levels and spirometric parameters were recorded in Shenyang, China. We observed that the median FeNO was 11 ppb (range, 8-16 ppb) in children from the northern areas of China. For males, the median level was 13 ppb (range, 9-18 ppb) and the median level was 10 ppb (range, 8-14 ppb) for females. There was a significant difference between males and females (P= 0.007) and age was correlated with FeNO (R= 0.6554), while weight, height, body mass index (BMI), forced vital capacity (FVC), forced expiratory volume (FEV1), FEV1/FVC and peak expiratory flow (PEF) had no correlation with FeNO. In conclusion, the median FeNO is 11 ppb (range, 8-16 ppb) in male and female healthy children from northern areas of China and is affected by gender and age.
哮喘是一种肺部慢性炎症性疾病，在儿童中诊断困难。呼出一氧化氮分数（FeNO）的测量可能有助于哮喘的诊断和治疗监测。许多因素会影响FeNO水平，且其影响在不同国家和地区有所不同。本研究纳入了300名6至14岁自愿参与的健康学生。在中国沈阳，采用了全面的医学调查，并记录了FeNO水平和肺功能参数的测量值。我们观察到，中国北方地区儿童的FeNO中位数为11 ppb（范围为8 - 16 ppb）。男性的中位数水平为13 ppb（范围为9 - 18 ppb），女性的中位数水平为10 ppb（范围为8 - 14 ppb）。男性和女性之间存在显著差异（P = 0.007），年龄与FeNO相关（R = 0.6554），而体重、身高、体重指数（BMI）、用力肺活量（FVC）、第一秒用力呼气容积（FEV1）、FEV1/FVC和呼气峰值流速（PEF）与FeNO无相关性。总之，中国北方地区健康儿童的FeNO中位数为11 ppb（范围为8 - 16 ppb），且受性别和年龄影响。
