老年男性的性腺功能状态与身体机能表现。
Gonadal status and physical performance in older men.
机构信息
Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Italy.
出版信息
Aging Male. 2011 Mar;14(1):42-7. doi: 10.3109/13685538.2010.518179. Epub 2010 Oct 12.
OBJECTIVE
To test the relationship between gonadal status and objective measures and determinants of physical performance in older men and their determinants.
METHODS
The study included 455 ≥ 65 year older men of InCHIANTI study, Italy, with complete data on testosterone levels, hand grip strength, cross-sectional muscle area (CSMA), short physical performance battery (SPPB). Linear models were used to test the relationship between gonadal status and determinants of physical performance.
RESULTS
Three different groups of older men were created: (1) severely hypogonadal (N=23), total testosterone levels ≤ 230 ng /dl; (2) moderately hypogonadal (N=88), total testosterone >230 and < 350 ng/dl) and (3) eugonadal (N=344), testosterone levels ≥ 350 ng/dl. With increased severity of hypogonadal status, participants were significantly older while their BMI was substantially similar. In the age and BMI adjusted analysis, there was a significant difference in haemoglobin levels, hand grip strength and SPPB score (p for trend < 0.001) among three groups, with severely hypogonadal men having lower values of haemoglobin, muscle strength and physical performance. We found no association between testosterone group assignment and calf muscle mass and 4 m walking speed. In the multivariate analysis grip strength (p for trend = 0.004) and haemoglobin (p for trend < 0.0001) but not SPPB and other determinants of physical performance were significantly different between the three groups.
CONCLUSIONS
In older men, gonadal status is independently associated with some determinants (haemoglobin and muscle strength) of physical performance.
目的
测试睾丸状态与老年男性身体机能的客观测量和决定因素及其决定因素之间的关系。
方法
该研究纳入了意大利因奇安蒂研究中的 455 名年龄≥65 岁的男性，他们的睾丸激素水平、握力、横截面积（CSA）和简短身体表现测试（SPPB）数据完整。线性模型用于测试睾丸状态与身体表现决定因素之间的关系。
结果
研究创建了三组不同的老年男性：（1）严重性腺功能减退症组（N=23），总睾酮水平≤230ng/dl；（2）中度性腺功能减退症组（N=88），总睾酮>230且<350ng/dl）和（3）性腺功能正常组（N=344），睾酮水平≥350ng/dl。随着性腺功能减退症严重程度的增加，参与者的年龄显著增加，而 BMI 则明显相似。在年龄和 BMI 调整分析中，三组之间的血红蛋白水平、握力和 SPPB 评分存在显著差异（趋势 p 值<0.001），严重性腺功能减退症男性的血红蛋白、肌肉力量和身体表现较低。我们没有发现睾酮组与小腿肌肉质量和 4 米步行速度之间存在关联。在多变量分析中，握力（趋势 p 值=0.004）和血红蛋白（趋势 p 值<0.0001）但不是 SPPB 和其他身体表现决定因素在三组之间存在显著差异。
结论
在老年男性中，睾丸状态与身体机能的一些决定因素（血红蛋白和肌肉力量）独立相关。
Zotero 插件