College of Life Sciences, Inner Mongolia Agricultural University, Hohhot 010018, China.
Lipids Health Dis. 2010 Oct 12;9:114. doi: 10.1186/1476-511X-9-114.
Tree shrew and beijing duck are regarded as animal models resistant to atherosclerosis (AS). This study was carried out to discover the potential mechanism.
Blood samples were collected from healthy men and male animals. Plasma lipid profile and activities of cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP) were measured, compared and analyzed in human, tree shrew, and Beijing duck.
The results showed that there were species differences on plasma lipid profile and activities of CETP and PLTP in the three species. Compared with human, tree shrew and beijing duck had higher high density lipoprotein cholesterol (HDL-C)/total cholesterol (TC) and HDL-C/low density lipoprotein cholesterol (LDL-C) ratios, but lower CETP and PLTP activities. In the three species, CETP and PLTP activities were negatively related with the ratio of HDL-C/LDL-C.
The present study suggested that low plasma CETP and PLTP activities may lead to a high HDL-C/LDL-C ratio and a high resistance to AS finally in tree shrew and beijing duck. Moreover, low PLTP activity may also make the animals resistant to AS by the relative high vitamin E content of apoB-containing lipoproteins and high anti-inflammatory and antioxidative properties of HDL particles. A detailed study in the future is recommended.
树鼩和北京鸭被认为是抗动脉粥样硬化（AS）的动物模型。本研究旨在探索其潜在机制。
采集健康男性和雄性动物的血液样本。测量、比较和分析人、树鼩和北京鸭的血浆脂质谱以及胆固醇酯转移蛋白（CETP）和磷脂转移蛋白（PLTP）的活性。
结果表明，这三种动物的血浆脂质谱以及 CETP 和 PLTP 的活性存在种属差异。与人类相比，树鼩和北京鸭的高密度脂蛋白胆固醇（HDL-C）/总胆固醇（TC）和 HDL-C/低密度脂蛋白胆固醇（LDL-C）比值较高，但 CETP 和 PLTP 活性较低。在这三种动物中，CETP 和 PLTP 活性与 HDL-C/LDL-C 比值呈负相关。
本研究表明，低血浆 CETP 和 PLTP 活性可能导致 HDL-C/LDL-C 比值升高，最终使树鼩和北京鸭具有抗 AS 能力。此外，低 PLTP 活性可能通过载脂蛋白 B 脂蛋白中相对较高的维生素 E 含量以及 HDL 颗粒的高抗炎和抗氧化特性，使动物具有抗 AS 能力。建议在未来进行更详细的研究。
