COGIMAGE, Centre de Recherche de l'Institut du Cerveau et de la Moelle, CRICM, UPMC-UMRS 975 INSERM-UMR 7225 CNRS, Hôpital de la Salpêtrière, Paris, France.
Neuroimage. 2011 Feb 1;54(3):1919-29. doi: 10.1016/j.neuroimage.2010.10.004. Epub 2010 Oct 21.
Although the spatial organization of visual areas can be revealed by functional Magnetic Resonance Imaging (fMRI), the synoptic, non-invasive access to the temporal characteristics of the information flow amongst distributed visual processes remains a technical and methodological challenge. Using frequency-encoded steady-state visual stimulation together with a combination of time-resolved functional magnetic source imaging from magnetoencephalography (MEG) and anatomical magnetic resonance imaging (MRI), this study evidences maps of visuotopic sustained oscillatory neural responses distributed across the visual cortex. Our results further reveal relative phase delays across responding striate and extra-striate visual areas, which thereby shape the chronometry of neural processes amongst these regions. The methodology developed in this study points at further developments in time-resolved analyses of distributed visual processes in the millisecond range, and to new ways of exploring the dynamics of functional processes within the human visual cortex non-invasively.
尽管功能磁共振成像 (fMRI) 可以揭示视觉区域的空间组织，但对分布的视觉过程之间的信息流的时间特征进行综合、非侵入性的访问仍然是一个技术和方法学上的挑战。本研究使用频率编码的稳态视觉刺激，结合脑磁图 (MEG) 和解剖磁共振成像 (MRI) 的时分辨功能磁源成像，证明了跨视皮层分布的视拓扑持续振荡神经反应图。我们的结果进一步揭示了在反应性纹状和纹外视觉区域之间的相对相位延迟，从而形成了这些区域之间神经过程的计时。本研究中开发的方法为毫秒范围内分布式视觉过程的时分辨分析的进一步发展指明了方向，并为探索人类视觉皮层内功能过程的动力学提供了新的非侵入性方法。
