Kim J Y, Bom H S, Kim Y J, Choi W
Division of Nuclear Medicine, Chonnam National University Hospital, Kwangju, Korea.
Radiat Med. 1990 Nov-Dec;8(6):246-9.
The purpose of the study is to investigate the value of adjuvant radiotherapy given in the form of colloidal chromic phosphate 32P suspension administered via portal vein, in preventing the growth of occult metastases in the liver. Twenty two patients (10 patients of treated group with 12 controls) were followed 12 months after operation. There was no significant change in the CBC and liver functions after administration of 32P labeled colloidal chromic phosphate. Although local recurrence rates were very similar in both groups of colorectal cancer (3/12 in the control group and 4/10 in the treated group), liver metastasis rates were quite different: 4/12 in the control group and none (0/10) in the treated group. In conclusion, 32P labeled colloidal chromic phosphate is expected to prevent liver metastases of completely resected colorectal cancer.
本研究的目的是探讨通过门静脉给予胶体磷酸铬32P悬浮液形式的辅助放疗在预防肝脏隐匿性转移灶生长方面的价值。22例患者（治疗组10例，对照组12例）术后随访12个月。给予32P标记的胶体磷酸铬后，血常规和肝功能无明显变化。虽然两组结直肠癌的局部复发率非常相似（对照组12例中有3例，治疗组10例中有4例），但肝转移率却有很大差异：对照组12例中有4例，治疗组无（10例中有0例）。总之，32P标记的胶体磷酸铬有望预防完全切除的结直肠癌肝转移。
