Gracheva I V, Orlova N V
Antibiotiki. 1975 Oct;20(10):871-6.
According to the literature data biosynthesis of novobiocin by Act. spheroides unlike other antibiotics does not practically depend on the phosphorus levels in the medium. In the present paper it is shown that production of novobiocin in natural media is sensitive to the concentration of mineral phosphorus in the medium. The optimal concentration of phosphorus for biosynthesis of novobiocin is almost within the same ranges as that for biosynthesis of streptomycin, tetracyclines and oleandomycin.
根据文献资料，与其他抗生素不同，球形放线菌合成新生霉素实际上并不依赖于培养基中的磷含量。本文表明，在天然培养基中新生霉素的产量对培养基中无机磷的浓度敏感。新生霉素生物合成的最佳磷浓度范围与链霉素、四环素和竹桃霉素生物合成的最佳磷浓度范围几乎相同。
