Bone and Joint Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
J Dent Res. 2010 Dec;89(12):1389-94. doi: 10.1177/0022034510381903. Epub 2010 Oct 12.
The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of periodontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n = 18) were tested for the presence of autoantibodies against: (a) native collagen type I (CI) and collagen type III (CIII); (b) CI and CIII post-translationally modified by reactive oxygen species (ROS) of the type present during inflammation; and (c) citrullinated filaggrin-derived peptides (CCP). Autoantibodies to native and ROS-modified CI and CIII as well as autoantibodies to CCP were observed exclusively in patients with AgP and not in those with CP or G. In conclusion, autoimmune reactions to native and post-translationally modified self-antigens may play a role specifically in the pathogenesis of AgP.
本研究旨在探讨自身免疫反应对天然和翻译后修饰的细胞外基质成分的参与在牙周炎发病机制中的作用。对侵袭性牙周炎（AgP，n=25）、慢性牙周炎（CP，n=14）和牙龈炎（G，n=18）患者的血清进行了针对以下物质的自身抗体检测：（a）天然胶原 I 型（CI）和胶原 III 型（CIII）；（b）由炎症期间存在的活性氧（ROS）翻译后修饰的 CI 和 CIII；以及（c）瓜氨酸化的微丝相关蛋白衍生肽（CCP）。仅在 AgP 患者中观察到针对天然和 ROS 修饰的 CI 和 CIII 以及针对 CCP 的自身抗体，而在 CP 或 G 患者中则没有观察到。总之，针对天然和翻译后修饰的自身抗原的自身免疫反应可能在 AgP 的发病机制中起特定作用。
