Focus issue: endocrine signaling from clinic to cell.

Disrupted or aberrant endocrine signaling has profound effects on the health of both children and adults. This issue focuses attention on endocrine signaling mediated by G protein-coupled receptor and receptor tyrosine kinase pathways involved in endocrine signaling, especially those critical in child development and health. Research in this issue highlights gender-specific differences in glucocorticoid signaling, which have implications for gender-specific treatment of inflammatory diseases.