远古大气与后生动物通过低氧诱导因子进行氧气感应的演化。
Ancient atmospheres and the evolution of oxygen sensing via the hypoxia-inducible factor in metazoans.
机构信息
UCD Conway Institute, Systems Biology Ireland and School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland.
出版信息
Physiology (Bethesda). 2010 Oct;25(5):272-9. doi: 10.1152/physiol.00029.2010.
Metazoan diversification occurred during a time when atmospheric oxygen levels fluctuated between 15 and 30%. The hypoxia-inducible factor (HIF) is a primary regulator of the adaptive transcriptional response to hypoxia. Although the HIF pathway is highly conserved, its complexity increased during periods when atmospheric oxygen concentrations were increasing. Thus atmospheric oxygen levels may have provided a selection force on the development of cellular oxygen-sensing pathways.
后生动物的多样化发生在大气氧水平在 15%至 30%之间波动的时期。缺氧诱导因子 (HIF) 是对缺氧适应转录反应的主要调节因子。尽管 HIF 途径高度保守，但在大气氧浓度增加的时期，其复杂性增加。因此，大气氧水平可能对细胞氧感应途径的发展提供了选择压力。
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