Murayama Shigeo, Saito Yuko
Department of Neuropathology and the Brain Bank for Aging Research,Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Sakae-cho, Itabashiku, Tokyo, Japan.
Brain Nerve. 2010 Oct;62(10):1013-8.
Brain Bank was established in 1960's in the United States and Europe as a basic infrastructure for human neuroscience research. In Japan,institutional collections are a substitute to brain banks and these function as the main repository of postmortem brains; Niigata University has one such center. The brain bank movement officially started in 2001 with the establishment of the Brain Bank for Aging Research (BBAR) in Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology. The Research Resource Network as well as the Brain Donation System of patients with Parkinson disease started in the National Center for Neurology and Psychiatry. A brain bank specially for psychiatric disorders was also established in Fukushima University. The Japanese Society of Neuropathology recognized the establishment of brain bank system as one of its major goals and the Brain Bank Committee worked as a task force. In 2010,the Japanese Brain Bank Network for Neuroscience Research (JBBNNR) was funded by Comprehensive Brain Science Network from the Ministry of Education,Culture,Sports,Science and Technology of Japan. BBAR was also appointed as the pathology core of Japanese Alzheimer Disease Neuroimage Initiative (JADNI) this year. The key features of JBBNNR are as follows. (1) The brain bank was approved by the institutional review board with the consensus of clinical and pathological branches of the neuroscience departments in the institute. (2) The brain bank accepts brain donation and maintains a clinical longitudinal follow-up record of the donor. (3) The brain bank resource is quality controlled and its information is shared by researchers. (4) The brain bank provides useful resources to researchers. Currently,JBBNNR includes Mihara Memorial Hospital Brain Bank and Fukushimura Brain Bank in addition to BBAR and it aims to expand the network for the creation of a future Japan Brain Net.
脑库于20世纪60年代在美国和欧洲建立，作为人类神经科学研究的基础基础设施。在日本，机构收藏是脑库的替代品，这些收藏充当死后大脑的主要储存库；新潟大学就有这样一个中心。脑库运动于2001年随着东京都老人综合医院和老年学研究所的老化研究脑库（BBAR）的建立而正式启动。国立精神神经医疗研究中心启动了研究资源网络以及帕金森病患者的脑捐赠系统。福岛大学还建立了一个专门针对精神疾病的脑库。日本神经病理学会将脑库系统的建立视为其主要目标之一，脑库委员会作为一个特别工作组开展工作。2010年，日本神经科学研究脑库网络（JBBNNR）由日本文部科学省的综合脑科学网络资助。BBAR今年还被指定为日本阿尔茨海默病神经影像计划（JADNI）的病理学核心。JBBNNR的主要特点如下。（1）该脑库经机构审查委员会批准，获得了该研究所神经科学系临床和病理部门的一致认可。（2）该脑库接受脑捐赠，并保存捐赠者的临床纵向随访记录。（3）该脑库资源经过质量控制，其信息供研究人员共享。（4）该脑库为研究人员提供有用的资源。目前，除了BBAR之外，JBBNNR还包括三原纪念医院脑库和深村脑库，其目标是扩大网络以创建未来的日本脑网。
