Akatsu Hiroyasu
Choju Medical Institute, Fukushimura Hospital, Yamanaka, Noyori-chou, Toyohashi-shi, Aichi, Japan.
Brain Nerve. 2010 Oct;62(10):1043-52.
Fukushimura Brain Bank (FBB) was established in 1994, and to date, has accumulated 477 fresh frozen brain tissue samples. Our brain bank is based in Choju Medical Institute, Fukushimura Hospital, Toyohashi in Japan. At the time of its foundation, the institute could not establish working relationships with clinicopathological investigators and others engaged in basic neuroscience research. At this stage, we received the assistance of Yokohama City University in setting up standards for neuropathological diagnosis as well as the aid of Chiba University in establishing a method for Vancouver style snap-frozen sampling of brain tissue. However, both systems require considerable manpower and time. We now plan to introduce several improvements in these systems. At its inception, the Brain Bank operated without financial support from grants or foundation funding and was managed only as a hospital expense. However, since 1998, we have collaborated with researchers from several institutes, and the results of our labors have been presented at congresses, in journal publications and in foundation reports. In 2004, we obtained the status required to apply for a grant from the Ministry of Education, Culture, Sports, Science and Technology of Japan. Fukushimura Hospital is a geriatric institution that specializes in dementia. There are no other hospitals or nursing homes in the Toyohashi area that specialize in this field. Half of our patients have Alzheimer's disease,and a number of them have enormous plaques and huge neurofibrillary tangles patient for over 10 years. In general,private geriatric hospitals that care for such patients with severe AD lack the systems required for performing autopsies. Research carried out with animal models are not comparable with neuropathological and biochemical investigations using human tissues,and in terms of the quality,the range and size of our collection at FBB is unique. In the future,we intend to expand our network in order to share samples of interest,and to optimize the network by establishing similar sampling protocols and diagnostic standards. It is with great pleasure that we at the FBB look forward to our collaboration with the Comprehensive Brain Science.
福岛村脑库（FBB）成立于1994年，截至目前，已积累了477份新鲜冷冻脑组织样本。我们的脑库位于日本丰桥市福岛村医院的长寿医学研究所。在其成立之时，该研究所无法与临床病理研究人员及其他从事基础神经科学研究的人员建立合作关系。在此阶段，我们得到了横滨市立大学在制定神经病理学诊断标准方面的协助，以及千叶大学在建立脑组织温哥华式速冻采样方法方面的帮助。然而，这两个系统都需要大量的人力和时间。我们现在计划对这些系统进行一些改进。脑库成立之初，没有来自赠款或基金会资金的财政支持，仅作为医院费用进行管理。然而，自1998年以来，我们与多个研究所的研究人员开展了合作，我们的工作成果已在大会上、期刊出版物和基金会报告中发表。2004年，我们获得了申请日本文部科学省赠款所需的资格。福岛村医院是一家专门治疗痴呆症的老年医疗机构。丰桥地区没有其他专门从事该领域的医院或养老院。我们一半的患者患有阿尔茨海默病，其中一些患者有大量斑块和巨大神经纤维缠结达10年以上。一般来说，照顾此类重度阿尔茨海默病患者的私立老年医院缺乏进行尸检所需的系统。使用动物模型进行的研究与使用人体组织进行的神经病理学和生化研究不可比，就质量而言，我们福岛村脑库样本的收集范围和规模是独一无二的。未来，我们打算扩大我们的网络，以便共享感兴趣的样本，并通过建立类似的采样方案和诊断标准来优化网络。福岛村脑库非常高兴期待与综合脑科学的合作。
