Division of Nuclear Medicine, Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI 48109-0028, USA.
Clin Nucl Med. 2010 Nov;35(11):865-9. doi: 10.1097/RLU.0b013e3181f4a16d.
The purpose of this article is to present our initial experience with hypersecretory adrenal syndromes investigated with radioiodinated I-6-B-iodomethyl-19-norcholesterol (NP-59) and SPECT-CT.
Illustrative cases are presented of patients being investigated for adrenal hypersecretory syndromes, with or without adrenal nodules, using NP-59 scintigraphy with SPECT-CT imaging, representing a spectrum of diagnoses. Clinical and imaging data are reviewed to evaluate whether additional information derived from near-simultaneous anatomic localization aids study interpretation.
The final diagnoses reached are hyperfunctional and nonfunctioning adrenal nodules, physiological bowel activity, and bilateral adrenal hyperplasia. SPECT-CT assisted study interpretation by localizing focal uptake to the adrenal glands, allowing direct assessment of function within adrenal nodules, and distinguishing physiological bowel activity from adrenal uptake. SPECT-CT provided additional information to planar and SPECT imaging, which improved confidence of study interpretation.
Utilization of SPECT-CT with NP-59 scintigraphy allows precise localization of the functional activity to anatomic structures improving diagnostic interpretation.
本文旨在介绍我们使用放射性碘标记 I-6-B-碘甲基-19-去甲胆固醇（NP-59）和 SPECT-CT 对高分泌性肾上腺综合征进行研究的初步经验。
本文介绍了使用 NP-59 闪烁扫描术和 SPECT-CT 成像对有或无肾上腺结节的高分泌性肾上腺综合征患者进行研究的典型病例，代表了一系列诊断。回顾临床和影像学数据，以评估来自近同期解剖定位的附加信息是否有助于研究解释。
最终诊断为功能性和无功能性肾上腺结节、生理性肠活动和双侧肾上腺增生。SPECT-CT 通过将局灶性摄取定位到肾上腺来辅助研究解释，允许直接评估肾上腺结节内的功能，并区分生理性肠活动与肾上腺摄取。SPECT-CT 提供了平面和 SPECT 成像的额外信息，提高了研究解释的信心。
NP-59 闪烁扫描术联合 SPECT-CT 的使用可精确定位功能活性的解剖结构，从而改善诊断解释。
