Samsonov V A, Gareginian S A, Polevaia O Iu
Vestn Dermatol Venerol. 1990(12):4-7.
Elevated levels of autoantibodies to types I-V collagens were detected in local scleroderma patients. In 75 percent of cases the levels of autoantibodies to types I and III collagens were elevated, in 30 percent to type II collagens, in 25 percent to type IV collagens, and in 20 percent to type V collagens. Anticollagen autoantibody levels did not differ from the normal values in the patients with a prolonged (for more than a year) remission. A reduction of these antibody levels almost to the normal values was achieved in 10-12 months after tigason therapy during a prolonged clinical remission. The ratio between autoantibodies to types I and II collagens was found to be a constant both in the donors and patients with local scleroderma.
在局限性硬皮病患者中检测到针对I - V型胶原蛋白的自身抗体水平升高。在75%的病例中，针对I型和III型胶原蛋白的自身抗体水平升高，30%针对II型胶原蛋白，25%针对IV型胶原蛋白，20%针对V型胶原蛋白。在病情长期缓解（超过一年）的患者中，抗胶原蛋白自身抗体水平与正常值无差异。在进行长期临床缓解的替加松治疗后10 - 12个月，这些抗体水平几乎降至正常值。发现I型和II型胶原蛋白自身抗体之间的比例在局限性硬皮病的供体和患者中都是恒定的。
