Hernández-Sánchez J, Chatzipli A, Beraldi D, Gratten J, Pilkington J G, Pemberton J M
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, EH9 3JT, UK.
Genet Res (Camb). 2010 Aug;92(4):273-81. doi: 10.1017/S0016672310000340.
Historical information can be used, in addition to pedigree, traits and genotypes, to map quantitative trait locus (QTL) in general populations via maximum likelihood estimation of variance components. This analysis is known as linkage disequilibrium (LD) and linkage mapping, because it exploits both linkage in families and LD at the population level. The search for QTL in the wild population of Soay sheep on St. Kilda is a proof of principle. We analysed the data from a previous study and confirmed some of the QTLs reported. The most striking result was the confirmation of a QTL affecting birth weight that had been reported using association tests but not when using linkage-based analyses.
除了系谱、性状和基因型外，历史信息还可用于通过方差成分的最大似然估计，在一般人群中定位数量性状基因座（QTL）。这种分析被称为连锁不平衡（LD）和连锁图谱分析，因为它利用了家族中的连锁和群体水平上的LD。在圣基尔达岛的索艾羊野生种群中寻找QTL就是一个原理验证。我们分析了之前一项研究的数据，并证实了一些报告的QTL。最引人注目的结果是证实了一个影响出生体重的QTL，该QTL已通过关联测试报告，但在基于连锁的分析中未被发现。
