来自普通拟杆菌的BVU2987的结构揭示了一个可能具有抑制功能的细菌周质蛋白超家族。
The structure of BVU2987 from Bacteroides vulgatus reveals a superfamily of bacterial periplasmic proteins with possible inhibitory function.
作者信息
Das Debanu, Finn Robert D, Carlton Dennis, Miller Mitchell D, Abdubek Polat, Astakhova Tamara, Axelrod Herbert L, Bakolitsa Constantina, Chen Connie, Chiu Hsiu Ju, Chiu Michelle, Clayton Thomas, Deller Marc C, Duan Lian, Ellrott Kyle, Ernst Dustin, Farr Carol L, Feuerhelm Julie, Grant Joanna C, Grzechnik Anna, Han Gye Won, Jaroszewski Lukasz, Jin Kevin K, Klock Heath E, Knuth Mark W, Kozbial Piotr, Krishna S Sri, Kumar Abhinav, Marciano David, McMullan Daniel, Morse Andrew T, Nigoghossian Edward, Nopakun Amanda, Okach Linda, Puckett Christina, Reyes Ron, Rife Christopher L, Sefcovic Natasha, Tien Henry J, Trame Christine B, van den Bedem Henry, Weekes Dana, Wooten Tiffany, Xu Qingping, Hodgson Keith O, Wooley John, Elsliger Marc André, Deacon Ashley M, Godzik Adam, Lesley Scott A, Wilson Ian A
机构信息
Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.
出版信息
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt 10):1265-73. doi: 10.1107/S1744309109046788. Epub 2010 Mar 5.
Proteins that contain the DUF2874 domain constitute a new Pfam family PF11396. Members of this family have predominantly been identified in microbes found in the human gut and oral cavity. The crystal structure of one member of this family, BVU2987 from Bacteroides vulgatus, has been determined, revealing a β-lactamase inhibitor protein-like structure with a tandem repeat of domains. Sequence analysis and structural comparisons reveal that BVU2987 and other DUF2874 proteins are related to β-lactamase inhibitor protein, PepSY and SmpA_OmlA proteins and hence are likely to function as inhibitory proteins.
包含DUF2874结构域的蛋白质构成了一个新的Pfam家族PF11396。该家族成员主要在人体肠道和口腔中的微生物中被鉴定出来。已确定该家族的一个成员，即来自脆弱拟杆菌的BVU2987的晶体结构，揭示了一种具有结构域串联重复的β-内酰胺酶抑制剂蛋白样结构。序列分析和结构比较表明，BVU2987和其他DUF2874蛋白与β-内酰胺酶抑制剂蛋白、PepSY和SmpA_OmlA蛋白相关，因此可能作为抑制蛋白发挥作用。
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