Department of Neurology, Myongji Hospital, College of Medicine, Kwandong University, Goyang, Korea.
J Clin Neurol. 2010 Sep;6(3):148-51. doi: 10.3988/jcn.2010.6.3.148. Epub 2010 Sep 30.
The clinical and pathological heterogeneity of progressive supranuclear palsy (PSP) is well established. Even with a well-defined clinical phenotype and a thorough laboratory workup, PSP can be misdiagnosed, especially in its early stages.
A 52-year-old woman, who we initially diagnosed with a behavioral variant of frontotemporal dementia developed parkinsonian features, which then progressed to gait instability and gaze abnormality.
We report herein a pathologically confirmed case of PSP presenting with behavioral changes including agitation and irritability, which eventually led to the cardinal symptoms of progressive supranuclear palsy.
进行性核上性麻痹（PSP）的临床和病理异质性是明确的。即使具有明确的临床表型和全面的实验室检查，PSP 仍可能被误诊，尤其是在早期阶段。
一位 52 岁女性，最初被诊断为额颞叶痴呆的行为变异型，随后出现帕金森病特征，随后进展为步态不稳和眼球异常。
我们在此报告一例经病理证实的 PSP 病例，其表现为行为改变，包括激越和易怒，最终导致进行性核上性麻痹的主要症状。
