Borges Felipe Placeres, Garcia Denny Marcos, Cruz Antonio Augusto Velasco E
Otorrinolaringology and Head and Neck Surgery Department, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo - USP, Ribeirão Preto, SP, Brazil.
Arq Bras Oftalmol. 2010 Jul-Aug;73(4):329-32. doi: 10.1590/s0004-27492010000400005.
To determine if the distribution of inter-blink time intervals is constant with repeated measurements with and without topical ocular anesthesia.
Inter-blink time was measured in 15 normal subjects ranging from 19 to 32 years (mean ± SD= 23.9 ± 3.20) with the magnetic search coil technique on 3 different occasions, the last one with topical ocular anesthesia.
One-way analysis of variance for repeated measurements showed that topical anesthesia significantly reduced the blink rate (blinks per minute), which was constant in the first two measurements (F=8.27, p=0.0015. First measurement: mean ± SD= 13.7 ± 7.8; second measurement: 13.1 ± 8.5 SD; with topical anesthesia: = 7.2 ± 4.6). However, distributions shape was not affected when the blink rate was reduced. The three distributions followed a Log Normal pattern, which means that the time interval between blinks was symmetrical when the time logarithm was considered.
Topical ocular anesthesia reduces the rate of spontaneous blinking, but does not change the distribution of inter-blink time interval.
确定在使用和不使用眼部表面麻醉剂进行重复测量时，眨眼间隔时间的分布是否恒定。
采用磁性搜索线圈技术，对15名年龄在19至32岁（平均±标准差=23.9±3.20）的正常受试者进行了3次不同情况下的眨眼间隔时间测量，最后一次测量时使用了眼部表面麻醉剂。
重复测量的单向方差分析表明，表面麻醉显著降低了眨眼频率（每分钟眨眼次数），前两次测量中眨眼频率恒定（F=8.27，p=0.0015。第一次测量：平均±标准差=13.7±7.8；第二次测量：13.1±8.5标准差；使用表面麻醉剂时：=7.2±4.6）。然而，当眨眼频率降低时，分布形状并未受到影响。这三种分布均遵循对数正态模式，这意味着当考虑时间对数时，眨眼间隔时间是对称的。
眼部表面麻醉降低了自发眨眼的频率，但并未改变眨眼间隔时间的分布。
