Department of Parasitology, Theodor Bilharz Research Institute, Giza, Egypt.
Mem Inst Oswaldo Cruz. 2010 Sep;105(6):729-35. doi: 10.1590/s0074-02762010000600001.
This work aimed to evaluate the effect of diphenyl dimethyl bicarboxylate (DDB) and dexamethasone alone and in combination with praziquantel on various parasitological, immunological and pathological parameters reflecting disease severity and morbidity in murine schistosomiasis. DDB and dexamethasone had no effect on worm burden but altered tissue egg distribution. This indicates that, under the schedule used, neither drug interfered with the development of adult worms or oviposition, but both can modulate liver pathology. Dexamethasone resulted in a greater reduction in granuloma size than did DDB. Dexamethasone-treated mice also showed lower levels of serum gamma interferon (IFN-γ), interleukin-12 (IL-12) and IL-4, together with higher IL-10 levels, than infected untreated control animals. These data suggest that dexamethasone is a convenient and promising coadjuvant agent that results in decreased morbidity in murine schistosomiasis.
本研究旨在评估二苯甲酰基甲烷（DDB）和地塞米松单独及联合应用于吡喹酮对反映严重度和发病的各种寄生虫学、免疫学和病理学参数的影响。DDB 和地塞米松对虫荷无影响，但改变了组织卵分布。这表明，在所使用的方案下，这两种药物均不干扰成虫发育或产卵，但均可调节肝病理。地塞米松导致的肉芽肿大小减少大于 DDB。与未治疗感染的对照动物相比，地塞米松治疗的小鼠的血清γ干扰素（IFN-γ）、白细胞介素-12（IL-12）和 IL-4 水平更低，而 IL-10 水平更高。这些数据表明，地塞米松是一种方便且有前途的佐剂，可降低小鼠血吸虫病的发病率。
