INSERM, U885, Bordeaux, France.
NMR Biomed. 2011 Apr;24(3):225-30. doi: 10.1002/nbm.1574. Epub 2010 Oct 13.
Pulmonary arterial hypertension (PAH) is a severe disease that leads to increased pulmonary vascular resistance and right heart failure. Noninvasive methods are needed to detect changes in the pulmonary artery circulation during PAH establishment and/or treatment. Pulmonary blood flow velocity can be evaluated by dynamic MR angiography, although the relevance of such data in the context of PAH remains to be demonstrated. A novel dynamic MR angiography technique was used in this work to measure blood flow velocity in the pulmonary arteries of the same living animals, before and after the establishment of chronic hypoxia-induced PAH. Chronic hypoxia decreased significantly the blood flow velocity (43.8 ± 4.9 vs 24.3 ± 8.7 cm/s) on electrocardiography-triggered time-resolved angiograms. In parallel, chronic hypoxia-induced PAH was confirmed from invasive measurements of the mean pulmonary arterial pressure (32.1 ± 4.8 vs 12.5 ± 2.2 mmHg) and the ratio of the right ventricle weight to the left ventricle plus septum weight (Fulton index: 0.54 ± 0.06 vs 0.27 ± 0.04). This study demonstrates the potential interest of dynamic MR angiography for the investigation of experimental models and for the evaluation of treatment efficacy.
肺动脉高压（PAH）是一种严重的疾病，可导致肺血管阻力增加和右心衰竭。需要非侵入性方法来检测 PAH 建立和/或治疗期间肺动脉循环的变化。可以通过动态磁共振血管造影评估肺血流速度，尽管这种数据在 PAH 中的相关性仍有待证明。本研究使用一种新型动态磁共振血管造影技术，在慢性低氧诱导的 PAH 建立前后，对同一活体动物的肺动脉血流速度进行测量。慢性低氧显著降低了心电图触发的时间分辨血管造影上的血流速度（43.8±4.9 对 24.3±8.7 cm/s）。平行地，从平均肺动脉压（32.1±4.8 对 12.5±2.2 mmHg）和右心室重量与左心室加室间隔重量的比值（富尔顿指数：0.54±0.06 对 0.27±0.04）的侵入性测量中证实了慢性低氧诱导的 PAH。本研究表明动态磁共振血管造影在实验模型研究和治疗效果评估方面具有潜在的应用价值。
