对约氏疟原虫子孢子保护性免疫的遗传限制。
Genetic restriction of protective immunity to Plasmodium yoelii sporozoites.
作者信息
Weiss W R, Good M F, Hollingdale M R, Miller L H, Berzofsky J A
机构信息
Infectious Disease Department, Naval Medical Research Institute, Bethesda, MD 20814.
出版信息
Bull World Health Organ. 1990;68 Suppl(Suppl):104-8.
Ten congenic strains of mice were immunized with irradiated sporozoites of Plasmodium yoelii. When challenged with viable sporozoites, only two strains had a high proportion of animals which did not develop blood-stage infections. Genes both within and outside the H-2 region affected the degree of protection. Immunity did not correlate with anti-sporozoite antibody levels. In vivo depletion of CD8+ T cells did not alter immunity in two of three congenic strains, implying the existence of a novel mechanism of cell-mediated immunity.
用约氏疟原虫的辐照子孢子对十株同源近交系小鼠进行免疫。当用活的子孢子进行攻击时，只有两株中有很大比例的动物未出现血期感染。H-2区域内外的基因均影响保护程度。免疫与抗子孢子抗体水平无关。在三株同源近交系中的两株中，体内清除CD8 + T细胞并未改变免疫力，这意味着存在一种新的细胞介导免疫机制。
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