Zavala F, Tam J P, Barr P J, Romero P J, Ley V, Nussenzweig R S, Nussenzweig V
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York 10016.
J Exp Med. 1987 Nov 1;166(5):1591-6. doi: 10.1084/jem.166.5.1591.
A synthetic peptide, (DPPPPNPN)2D, representing a subunit of the repeat domain of the Plasmodium berghei circumsporozoite protein, was conjugated to tetanus toxoid using bisdiazobenzidine. Immunization of mice and rats with the conjugate induced high serum titers of antibodies to the parasite, and most of the animals were completely protected from malaria infection when challenged with sporozoites.
一种合成肽（DPPPPNPN）2D，代表伯氏疟原虫环子孢子蛋白重复结构域的一个亚基，使用双偶氮联苯胺与破伤风类毒素偶联。用该偶联物免疫小鼠和大鼠可诱导产生高血清滴度的抗寄生虫抗体，并且大多数动物在用子孢子攻击时完全免受疟疾感染。
