Research Centre for Synthesis and Catalysis, Department of Chemistry, University of Johannesburg, P.O. Box 524, Auckland Park 2006, South Africa.
J Org Chem. 2010 Dec 17;75(24):8351-4. doi: 10.1021/jo101589h. Epub 2010 Oct 14.
Various commonly used organic solvents were dried with several different drying agents. A glovebox-bound coulometric Karl Fischer apparatus with a two-compartment measuring cell was used to determine the efficiency of the drying process. Recommendations are made relating to optimum drying agents/conditions that can be used to rapidly and reliably generate solvents with low residual water content by means of commonly available materials found in most synthesis laboratories. The practical method provides for safer handling and drying of solvents than methods calling for the use of reactive metals, metal hydrides, or solvent distillation.
多种常用有机溶剂使用不同的干燥剂干燥。使用具有双室测量池的手套箱绑定库仑卡尔费休法测定干燥过程的效率。提出了与最佳干燥剂/条件有关的建议，这些干燥剂/条件可以使用大多数合成实验室中常见的材料快速且可靠地生成具有低残留水分的溶剂。与使用反应性金属、金属氢化物或溶剂蒸馏的方法相比，该实用方法更安全地处理和干燥溶剂。
