通过钯催化作用，使金属化氮丙啶与芳基和烯基卤化物进行交叉偶联。
Metalated aziridines for cross-coupling with aryl and alkenyl halides via palladium catalysis.
机构信息
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
出版信息
Org Lett. 2010 Nov 19;12(22):5085-7. doi: 10.1021/ol101904a. Epub 2010 Oct 14.
Abstract
The palladium-catalyzed coupling of an aziridinylzinc chloride intermediate with alkenyl and aryl halides has been demonstrated. The method provides products with retention of aziridine stereochemistry. The utility of the coupling procedure is illustrated in the synthesis of structures related to l-furanomycin.
摘要
钯催化的氮丙啶基氯化锌中间体与烯基和芳基卤化物的偶联已经得到证明。该方法提供了保留氮丙啶立体化学的产物。该偶联步骤的实用性在与 l-呋喃霉素相关的结构的合成中得到了说明。
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A General Approach to L-(+)-Furanomycin and Some Stereoisomers and Analogues Using Furoisoxazoline Intermediates Syntheses via Isoxazolines, Part 24. Part of the planned dissertation of P. J. Zimmermann. We thank the Volkswagen-Stiftung, Hannover, the Fonds der Chemischen Industrie, the Landesgraduiertenförderung Baden-Württemberg (doctoral fellowship to P.J.Z.), and Bayer AG, Wuppertal, for financial support of this work. I.B. gratefully acknowledges a grant from the Volkswagen-Stiftung for a research stay at Stuttgart. We thank Dr. W. Frey for the X-ray crystal structure determinations. This work was presented at the 17th ICHC, Vienna, in August 1999, Book of Abstracts OP-61. Part 23: ref. 1.
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