Parkinson's Disease Research, Education & Clinical Center, Philadelphia VA Medical Center & Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Biomark Med. 2010 Oct;4(5):661-70. doi: 10.2217/bmm.10.95.
Olfactory dysfunction in Parkinson's disease is common and of interest, both as a clinical finding and potential biomarker. In this article, we discuss studies characterizing the olfactory deficit in Parkinson's disease and pathological analysis that suggests the olfactory system is a likely induction site of the neurodegenerative process. These studies have enabled research to explore the potential of olfactory dysfunction as a key component in early diagnostic strategies, as a biomarker for diagnostic purposes, a predictor of clinical outcomes and a potential therapy-independent marker of disease progression.
帕金森病患者的嗅觉功能障碍很常见，也很受关注，既是一种临床发现，也是一种有潜力的生物标志物。本文讨论了帕金森病嗅觉缺陷的特征研究和病理分析，这些研究表明嗅觉系统可能是神经退行性过程的诱导部位。这些研究使研究人员能够探索嗅觉功能障碍作为早期诊断策略的关键组成部分、诊断标志物、临床结果预测因子以及疾病进展的潜在独立于治疗的标志物的潜力。
