Wang Xin-Yi, Han Ying-Ying, Li Gang, Zhang Bei
Department of Neurology, East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Shanghai, 200123, China.
BMC Neurol. 2019 Feb 2;19(1):17. doi: 10.1186/s12883-019-1243-4.
The aim was to investigate the autonomic dysfunction between Parkinson's disease (PD) patients with olfactory dysfunction and PD patients without olfactory dysfunction in southern Chinese population.
Fifty-six PD patients with olfactory dysfunction and 44 patients without olfactory dysfunction were included. All patients were evaluated by Sniffin' sticks (SS-16), scales for outcomes in Parkinson's disease-autonomic questionnaire, Hamilton anxiety rating scale and Hamilton depression rating scale RESULTS: The score of subpart of gastrointestinal symptoms and subpart of urinary symptoms were different in two groups (gastrointestinal symptoms: p value: 0.024; urinary symptoms: p value: 0.008). As for each question items, questions 2, 8, 10, 11, 13, 14 were correlated with SS-16 scores (Question 2: p value: 0.013; question 6: p value: 0.006; question 8: p value: 0.025; question 10: p value: 0.005; question 11: p value: 0.022; question 13: p value: < 0.001; question 14: p value: 0.038). Question 10 and 14 were associated with olfactory dysfunction after adjusting disease duration and gender (Question 10: p value: 0.011, OR: 3.91; Question 14: p value: 0.027, OR: 3.27).
Gastrointestinal, urinary and a part of cardiovascular symptoms of SCOPA-AUT were associated with olfactory dysfunction in PD patients.
目的是研究中国南方帕金森病（PD）嗅觉功能障碍患者与无嗅觉功能障碍的PD患者之间的自主神经功能障碍。
纳入56例有嗅觉功能障碍的PD患者和44例无嗅觉功能障碍的患者。所有患者均采用嗅觉棒测试（SS-16）、帕金森病自主神经问卷结局量表、汉密尔顿焦虑评定量表和汉密尔顿抑郁评定量表进行评估。结果：两组患者的胃肠道症状子部分和泌尿系统症状子部分得分不同（胃肠道症状：p值：0.024；泌尿系统症状：p值：0.008）。对于每个问题项目，问题2、8、10、11、13、14与SS-16得分相关（问题2：p值：0.013；问题6：p值：0.006；问题8：p值：0.025；问题10：p值：0.005；问题11：p值：0.022；问题13：p值：<0.001；问题14：p值：0.038）。在调整病程和性别后，问题10和14与嗅觉功能障碍相关（问题10：p值：0.011，比值比：3.91；问题14：p值：0.027，比值比：3.27）。
帕金森病自主神经症状量表（SCOPA-AUT）中的胃肠道、泌尿系统及部分心血管系统症状与帕金森病患者的嗅觉功能障碍有关。
