Center for Human Nutrition, University of California Los Angeles, Los Angeles, CA, USA.
Nutr J. 2010 Oct 14;9:44. doi: 10.1186/1475-2891-9-44.
Decreased bone mineral density and osteoporosis in postmenopausal women represents a growing source of physical limitations and financial concerns in our aging population. While appropriate medical treatments such as bisphosphonate drugs and hormone replacement therapy exist, they are associated with serious side effects such as osteonecrosis of the jaw or increased cardiovascular risk. In addition to calcium and vitamin D supplementation, previous studies have demonstrated a beneficial effect of dietary silicon on bone health. This study evaluated the absorption of silicon from bottled artesian aquifer water and its effect on markers of bone metabolism.
Seventeen postmenopausal women with low bone mass, but without osteopenia or osteoporosis as determined by dual x-ray absorptiometry (DEXA) were randomized to drink one liter daily of either purified water of low-silicon content (PW) or silicon-rich artesian aquifer water (SW) (86 mg/L silica) for 12 weeks. Urinary silicon and serum markers of bone metabolism were measured at baseline and after 12 weeks and analyzed with two-sided t-tests with p < 0.05 defined as significant.
The urinary silicon level increased significantly from 0.016 ± 0.010 mg/mg creatinine at baseline to 0.037 ± 0.014 mg/mg creatinine at week 12 in the SW group (p = 0.003), but there was no change for the PW group (0.010 ± 0.004 mg/mg creatinine at baseline vs. 0.009 ± 0.006 mg/mg creatinine at week 12, p = 0.679). The urinary silicon for the SW group was significantly higher in the silicon-rich water group compared to the purified water group (p < 0.01). NTx, a urinary marker of bone resorption did not change during the study and was not affected by the silicon water supplementation. No significant change was observed in the serum markers of bone formation compared to baseline measurements for either group.
These findings indicate that bottled water from artesian aquifers is a safe and effective way of providing easily absorbed dietary silicon to the body. Although the silicon did not affect bone turnover markers in the short-term, the mineral's potential as an alternative prevention or treatment to drug therapy for osteoporosis warrants further longer-term investigation in the future.
ClinicalTrials.gov Identifier: NCT01067508.
绝经后妇女的骨密度降低和骨质疏松症是我们老龄化人口中日益严重的身体限制和经济问题的根源。虽然存在适当的医疗治疗方法，如双磷酸盐药物和激素替代疗法，但它们与严重的副作用有关，如颌骨坏死或增加心血管风险。除了钙和维生素 D 补充剂外，先前的研究表明饮食硅对骨骼健康有益。本研究评估了从瓶装自流井水吸收硅及其对骨代谢标志物的影响。
17 名患有低骨量的绝经后妇女，根据双能 X 射线吸收法（DEXA）确定无骨质减少或骨质疏松症，随机分为每天饮用一升低硅含量的纯净水（PW）或富含硅的自流井水（SW）（86mg/L 硅），为期 12 周。在基线和 12 周后测量尿硅和血清骨代谢标志物，并使用双侧 t 检验进行分析，p<0.05 定义为有统计学意义。
SW 组尿硅水平从基线时的 0.016±0.010mg/mg 肌酐显著升高至 12 周时的 0.037±0.014mg/mg 肌酐（p=0.003），而 PW 组无变化（基线时为 0.010±0.004mg/mg 肌酐，12 周时为 0.009±0.006mg/mg 肌酐，p=0.679）。SW 组尿硅明显高于 PW 组（p<0.01）。尿骨吸收标志物 NTx 在研究期间没有变化，也不受硅水补充的影响。与基线相比，两组的血清骨形成标志物均无明显变化。
这些发现表明，自流井水是一种安全有效的方法，可以为身体提供易于吸收的饮食硅。尽管硅在短期内没有影响骨转换标志物，但这种矿物质作为骨质疏松症药物治疗的替代或预防方法的潜力值得未来进行更长期的研究。
ClinicalTrials.gov 标识符：NCT01067508。
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