生殖细胞迁移的要点。

The nuts and bolts of germ-cell migration.

机构信息

Institute of Cell Biology, Center for Molecular Biology of Inflammation, Von-Esmarch-Str. 56, 48149, Münster University, 48147 Münster, Germany.

出版信息

Curr Opin Cell Biol. 2010 Dec;22(6):715-21. doi: 10.1016/j.ceb.2010.09.005. Epub 2010 Oct 13.

DOI:10.1016/j.ceb.2010.09.005

PMID:20947321

Abstract

In many species, primordial germ cells (PGCs) migrate from the position where they are specified to the site where the gonad develops, where they differentiate into sperm and egg. Germ cells thus serve as an excellent model for studying cell migration in the context of the live organism. In recent years, a number of cues directing the migration of the cells towards their target were identified and some of the relevant molecules and biochemical pathways were revealed. In this review we present those results, focusing on 'cell mechanics' of the process including cell adhesion, traction generation and cell polarization.

摘要

在许多物种中，原始生殖细胞（PGCs）从指定位置迁移到性腺发育的部位，在那里分化为精子和卵子。因此，生殖细胞是研究活生物体中细胞迁移的理想模型。近年来，已经确定了一些指导细胞向其靶标迁移的信号，并且揭示了一些相关的分子和生化途径。在这篇综述中，我们介绍了这些结果，重点介绍了包括细胞黏附、牵引力产生和细胞极化在内的“细胞力学”过程。