Asklepios Neurological Hospital Falkenstein, Königstein/Taunus, Germany.
Cerebrovasc Dis. 2010;30(6):584-9. doi: 10.1159/000319777. Epub 2010 Oct 14.
In this study, we tried to identify predictors of acute poststroke seizures (aPSS) in stroke patients.
We analyzed a large prospective hospital-based stroke registry in Germany. 58,874 patients with the diagnosis of transient ischemic attack (TIA), ischemic stroke (IS) or intracerebral hemorrhage (ICH) were admitted within 24 h after symptom onset. Predictors for aPSS were identified using multivariate regression analysis adjusted for age, gender, stroke severity, vascular risk factors, acute nonneurologic infection, history of TIA and length of hospital stay.
aPSS occurred in 0.7% of patients with TIA (mean duration of hospitalization 8 days), in 2.2% of patients with IS (12 days) and in 5.1% of patients with ICH (13 days). A lower age, a higher stroke severity, acute nonneurologic infection, a history of diabetes mellitus and a history of preceding TIA were identified to be independent predictors of aPSS in IS, whereas younger age, acute infection and a history of TIA were found predictive for aPSS in ICH.
This study characterized so far unknown predictors of aPSS and may help to improve the identification of patients with a high risk of aPSS.
在本研究中，我们试图确定脑卒中后急性发作性癫痫（aPSS）的预测因素。
我们分析了德国一项大型前瞻性基于医院的脑卒中登记研究。58874 例短暂性脑缺血发作（TIA）、缺血性脑卒中（IS）或脑出血（ICH）患者在症状发作后 24 小时内入院。使用多变量回归分析，根据年龄、性别、脑卒中严重程度、血管危险因素、急性非神经系统感染、TIA 病史和住院时间，确定 aPSS 的预测因素。
TIA 患者中 aPSS 的发生率为 0.7%（平均住院时间为 8 天），IS 患者为 2.2%（12 天），ICH 患者为 5.1%（13 天）。较低的年龄、较高的脑卒中严重程度、急性非神经系统感染、糖尿病史和 TIA 病史是 IS 中 aPSS 的独立预测因素，而年龄较小、急性感染和 TIA 病史是 ICH 中 aPSS 的预测因素。
本研究描述了迄今为止未知的 aPSS 预测因素，有助于提高对 aPSS 高危患者的识别。
