Patel Kalpesh, Taub Dennis D
Laboratory of Immunology, National Institute of Aging, Intramural Research Program, National Institutes of Health, Biomedical Research Center 251 Bayview Boulevard, Room 8C222, Baltimore, MD 21224 USA.
F1000 Biol Rep. 2009 May 28;1:42. doi: 10.3410/B1-42.
The deterioration in adaptive immunity and T-lymphocyte output and the narrowing of the T cell receptor repertoire with age are largely attributable to thymic involution. The loss of thymic function with age may be due to diminished numbers of early thymic progenitors and epithelial cells, and the loss of critical tropic factors within the thymic microenvironment. Here we review some of the recent literature demonstrating a role for neuropeptides, hormones, and growth factors that can influence thymopoiesis associated with stress and aging.
随着年龄增长，适应性免疫和T淋巴细胞输出功能的衰退以及T细胞受体库的变窄在很大程度上归因于胸腺退化。随着年龄增长胸腺功能的丧失可能是由于早期胸腺祖细胞和上皮细胞数量减少，以及胸腺微环境中关键促生长因子的丧失。在此，我们综述一些近期文献，这些文献表明神经肽、激素和生长因子在影响与应激和衰老相关的胸腺生成中所起的作用。
