Taub Dennis D
Laboratory of Immunology, Clinical Immunology Section, National Institute of Aging-Intramural Research Program, National Institute of Health, Baltimore, MD 21224-6825, USA.
Cell Immunol. 2008 Mar-Apr;252(1-2):1-6. doi: 10.1016/j.cellimm.2008.05.006. Epub 2008 Jul 10.
Substantial evidence now exists supporting the bidirectional communication between the neuroendocrine and immune systems. A number of hormonal and neuropeptide mediators have been shown to influence immune development and function in healthy, aged and diseased individuals. Immune cell subsets express receptors for many of these ligands and similarly, receptors for cytokines and growth factors have been identified on cells within the central nervous and endocrine systems. During times of stress or injury, each of these systems come into play and transmits messages to one another. The lines of communication between the immune system and these various neuronal and endocrine organ systems constitute specific axes of interactions, which have been shown to have a profound impact on immune function, disease development and susceptibility to infections and disease. In this Special Issue, experts in neuroendocrine immunology have provided comprehensive reviews on the current advances in this area of research as well as commentary on relevance of the various axes in controlling immunity and disease development.
现在有大量证据支持神经内分泌系统和免疫系统之间的双向通信。已证明多种激素和神经肽介质会影响健康、老年和患病个体的免疫发育和功能。免疫细胞亚群表达许多这些配体的受体，同样，在中枢神经和内分泌系统的细胞上也已鉴定出细胞因子和生长因子的受体。在压力或损伤时期，这些系统中的每一个都会发挥作用并相互传递信息。免疫系统与这些不同的神经元和内分泌器官系统之间的通信线路构成了特定的相互作用轴，已证明这些轴对免疫功能、疾病发展以及感染和疾病易感性具有深远影响。在本期特刊中，神经内分泌免疫学领域的专家对该研究领域的当前进展以及各轴在控制免疫和疾病发展中的相关性进行了全面综述。
